- Clementi West Region (Singapore) Singapore
Kerja Sepenuh Masa Bioinformatics Scientist: tNGS Panels, Gaji tinggi SGD 8,000 di AITBIOTECH PTE. LTD. West Region (Singapore) - Maukerja
Bioinformatics Scientist: tNGS Panels
AITBIOTECH PTE. LTD.
Kongsi
Simpan
Lokasi Kerja
Penerangan Kerja
Tanggungjawab
AITbiotech Pte Ltd ·Singapore · Full-time · Bachelor or MSc level
About the role
At AITbiotech we develop molecular diagnostics and genomics solutions, and we are building a growing menu of targeted NGS panels that run on our benchtop abSEQ sequencer with on-site analysis and reporting: solid-tumour profiling with hereditary cancer, inherited cardiac disease, a large comprehensive cancer panel, and infectious disease.
Our R&D team builds the analysis pipelines and the AI behind them. We are looking for a scientist to own the layer on top: run those pipelines across the whole panel menu, curate the clinical knowledge base, interpret and classify variants, and draft the reports that turn sequencing data into a clinical result.
This is a cross-panel role in a small team. You will work with the R&D Director, who leads pipeline and AI development, with the laboratory team and Quality, and with a clinician advisor who signs out cases. If you enjoy variant interpretation and curation and want breadth across somatic and germline testing rather than a single assay, this is that role.
Key Responsibilities
Analysis and QC across the panel menu
Run and monitor the NGS analysis pipelines on the abSEQ platform and on-site software across the panel menu, and check run- andsample-level QC, flagging and following up failures.
Use scripts (Python, R or bash) to handle, QC and summarize data. The pipelines themselves are built and maintained by the R&D team, so this is applying and configuring them, not developing them.
Variant curation and interpretation
Curate and maintain the clinical knowledge base: variant classifications, gene-disease and variant-drug evidence, kept current with guidelines and the literature.
Tier somatic variants (CAP/AMP/ASCO) for tumor profiling and classify germline variants (ACMG/AMP) for hereditary cancer and inherited cardiac testing.
Draft structured, therapy-linked or condition-linkedreports for review and sign-off by a qualified professional.
Validation support
Analyse and tabulate data from analytical and clinical validation studies across panels (concordance, limit of detection, precision) and investigate discordances with orthogonal methods.
Provide the analysis outputs and summaries that feed the validation and design-control records, which Quality maintains.
Continuous improvement
Feed interpretation and QC findings back to the R&D team to improve the pipelines, the AI and the knowledge base.
Maintain analysis records, interpretation versioning and traceability.
What we're looking for
Essential
Bachelor's or Master's in Bioinformatics, Genetics, Genomics, Molecular biology or a related field
.
3 to 5 years working experience in related field.
Experience interpreting NGS variant data: comfortable with coverage, variant allele fraction and variant evidence, with familiarity with somatic tiering (CAP/AMP/ASCO) and/or germline classification (ACMG/AMP).
Comfortable on the Linux command line and running bioinformatics tools and pipelines, and able to use Python, R or bash to handle and QC data (building pipelines is the R&D team's job).
Familiarity with variant databases and resources such as ClinVar, COSMIC, gnomAD, OncoKB and the ACMG criteria.
Accurate, methodical and well-documented work, and clear written English for clinical reports.
Advantageous, not required
Clinical or diagnostic variant curation or reporting experience.
Both somatic and germline interpretation.
Oncology, hereditary cancer, or inherited cardiac genetics.
Experience with MGI or Illumina data, hybrid-capturepanels, FFPE and cell-free DNA.
Exposure to ISO 15189 or ISO 13485 or regulated clinical reporting.
What you get
Breadth across a whole pipeline.
Solid-tumour profiling, hereditary cancer, inherited cardiac disease, a large comprehensive cancer panel and infectious disease, rather than one assay.
You own interpretation and reporting.
Your work turns sequencing into a clinical result, while the R&D team builds the pipelines and AI behind you.
Room to grow.
Scope to become theclinical-genomics and reporting lead as the panel menu expands.
Small company, real decisions, and a short distance between your work and whether a result reaches a patient.
Company Profile
Founded in 2008 by biotechnology entrepreneur Alex Thian and Sue Yap with the vision of building a leading biotechnology company, AITbiotech has grown to become a leading Molecular Diagnostic (MDx), Molecular Services and Life Science Products provider in Singapore and ASIA. AITbiotech has an ISO13485 certified laboratory. It is also bizSAFE level 3 as well as GDPMDS certified.
AITbiotech is a world leader in multiplex real-time PCR (qPCR) assays for tropical infectious diseases. Its multiplex qPCR assays, marketed under the abTESTM including the Influenza 4-plex and Dengue 4-plex assays are being used by many major hospitals in Singapore and Asean.
Focusing on using latest genomics technology tools, AITbiotech offers high quality and consistent Molecular Services to the Asian research and biomedical markets.
About the role
At AITbiotech we develop molecular diagnostics and genomics solutions, and we are building a growing menu of targeted NGS panels that run on our benchtop abSEQ sequencer with on-site analysis and reporting: solid-tumour profiling with hereditary cancer, inherited cardiac disease, a large comprehensive cancer panel, and infectious disease.
Our R&D team builds the analysis pipelines and the AI behind them. We are looking for a scientist to own the layer on top: run those pipelines across the whole panel menu, curate the clinical knowledge base, interpret and classify variants, and draft the reports that turn sequencing data into a clinical result.
This is a cross-panel role in a small team. You will work with the R&D Director, who leads pipeline and AI development, with the laboratory team and Quality, and with a clinician advisor who signs out cases. If you enjoy variant interpretation and curation and want breadth across somatic and germline testing rather than a single assay, this is that role.
Key Responsibilities
Analysis and QC across the panel menu
Run and monitor the NGS analysis pipelines on the abSEQ platform and on-site software across the panel menu, and check run- andsample-level QC, flagging and following up failures.
Use scripts (Python, R or bash) to handle, QC and summarize data. The pipelines themselves are built and maintained by the R&D team, so this is applying and configuring them, not developing them.
Variant curation and interpretation
Curate and maintain the clinical knowledge base: variant classifications, gene-disease and variant-drug evidence, kept current with guidelines and the literature.
Tier somatic variants (CAP/AMP/ASCO) for tumor profiling and classify germline variants (ACMG/AMP) for hereditary cancer and inherited cardiac testing.
Draft structured, therapy-linked or condition-linkedreports for review and sign-off by a qualified professional.
Validation support
Analyse and tabulate data from analytical and clinical validation studies across panels (concordance, limit of detection, precision) and investigate discordances with orthogonal methods.
Provide the analysis outputs and summaries that feed the validation and design-control records, which Quality maintains.
Continuous improvement
Feed interpretation and QC findings back to the R&D team to improve the pipelines, the AI and the knowledge base.
Maintain analysis records, interpretation versioning and traceability.
What we're looking for
Essential
Bachelor's or Master's in Bioinformatics, Genetics, Genomics, Molecular biology or a related field
.
3 to 5 years working experience in related field.
Experience interpreting NGS variant data: comfortable with coverage, variant allele fraction and variant evidence, with familiarity with somatic tiering (CAP/AMP/ASCO) and/or germline classification (ACMG/AMP).
Comfortable on the Linux command line and running bioinformatics tools and pipelines, and able to use Python, R or bash to handle and QC data (building pipelines is the R&D team's job).
Familiarity with variant databases and resources such as ClinVar, COSMIC, gnomAD, OncoKB and the ACMG criteria.
Accurate, methodical and well-documented work, and clear written English for clinical reports.
Advantageous, not required
Clinical or diagnostic variant curation or reporting experience.
Both somatic and germline interpretation.
Oncology, hereditary cancer, or inherited cardiac genetics.
Experience with MGI or Illumina data, hybrid-capturepanels, FFPE and cell-free DNA.
Exposure to ISO 15189 or ISO 13485 or regulated clinical reporting.
What you get
Breadth across a whole pipeline.
Solid-tumour profiling, hereditary cancer, inherited cardiac disease, a large comprehensive cancer panel and infectious disease, rather than one assay.
You own interpretation and reporting.
Your work turns sequencing into a clinical result, while the R&D team builds the pipelines and AI behind you.
Room to grow.
Scope to become theclinical-genomics and reporting lead as the panel menu expands.
Small company, real decisions, and a short distance between your work and whether a result reaches a patient.
Company Profile
Founded in 2008 by biotechnology entrepreneur Alex Thian and Sue Yap with the vision of building a leading biotechnology company, AITbiotech has grown to become a leading Molecular Diagnostic (MDx), Molecular Services and Life Science Products provider in Singapore and ASIA. AITbiotech has an ISO13485 certified laboratory. It is also bizSAFE level 3 as well as GDPMDS certified.
AITbiotech is a world leader in multiplex real-time PCR (qPCR) assays for tropical infectious diseases. Its multiplex qPCR assays, marketed under the abTESTM including the Influenza 4-plex and Dengue 4-plex assays are being used by many major hospitals in Singapore and Asean.
Focusing on using latest genomics technology tools, AITbiotech offers high quality and consistent Molecular Services to the Asian research and biomedical markets.
Peringatan Penting
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